# A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases

Source: https://onco.cc/trials/nct07357220/  
OnCo record `nct07357220` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of ivonescimab in colorectal cancer, run by Akeso, not yet recruiting.

## Summary

A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases is a phase 1/2, randomised interventional study registered as NCT07357220 by Akeso, with a registry enrolment figure of 72 participants, started 2026-03-02 and due to reach its primary completion in 2027-02-28. Interventions recorded: VG2025; AK112. Conditions listed: Colorectal Cancer With Hepatic Metastases. Primary outcome: Number of participants experiencing dose-limiting toxicities (DLTs); Number of participants with adverse events (AEs) and severity; Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed unresectable colorectal cancer with liver metastases; adenocarcinoma type". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07357220
- Phase: 1/2
- Setting: A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of AK112 in Combination With VG2025 in Patients With Advanced Colorectal Cancer With Liver Metastases
- Sponsor: Akeso
- Enrolled: 72

## Sources

- ClinicalTrials.gov NCT07357220: https://clinicaltrials.gov/study/NCT07357220

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- companies: [Akeso](https://onco.cc/companies/akeso/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07357220.json