# Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

Source: https://onco.cc/trials/nct07359456/  
OnCo record `nct07359456` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab and bevacizumab (glioblastoma use) in colorectal cancer, run by UNICANCER, not yet recruiting.

## Summary

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases is a phase 2, randomised interventional study registered as NCT07359456 by UNICANCER, with a registry enrolment figure of 130 participants, started 2026-08-31 and due to reach its primary completion in 2029-08. Interventions recorded: Ivonescimab; Bevacizumab; FOLFIRI Protocol. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Progression Free Survival (PFS). Colorectal eligibility wording from the registry: "Histologically confirmed diagnosis of non resectable pMMR (by IHC) and MSS (by molecular biology) and BRAFwt metastatic colorectal cancer with no liver metastasis". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: COLIBRI-GI
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07359456
- Phase: 2
- Setting: Randomized Phase 2 Study of Second-line Chemotherapy Comparing FOLFIRI + Ivonescimab Versus FOLFIRI + Bevacizumab in Microsatellite Stable (MSS)/ Proficient MisMatch Repair (pMMR) BRAF Wild Type (BRAFwt) Advanced Colorectal Cancer (mCRC) Without Liver Metastases
- Sponsor: UNICANCER
- Enrolled: 130

## Sources

- ClinicalTrials.gov NCT07359456: https://clinicaltrials.gov/study/NCT07359456

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- companies: [Summit Therapeutics](https://onco.cc/companies/summit-therapeutics/), [UNICANCER](https://onco.cc/companies/unicancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07359456.json