# Fruquintinib Versus Bevacizumab Plus Chemotherapy in Second-Line RAS-Mutant Metastatic Colorectal Cancer (FRU-RAS)

Source: https://onco.cc/trials/nct07362836/  
OnCo record `nct07362836` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fruquintinib and bevacizumab (glioblastoma use) in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

Fruquintinib Versus Bevacizumab Plus Chemotherapy in Second-Line RAS-Mutant Metastatic Colorectal Cancer (FRU-RAS) is a phase 3, randomised interventional study registered as NCT07362836 by Fudan University, with a registry enrolment figure of 224 participants, started 2026-01-31 and due to reach its primary completion in 2028-12-30. Interventions recorded: fruquintinib+chemotherapy; bevacizumab+chemotherapy. Conditions listed: Colorectal Cancer. Primary outcome: Progression-Free Survival. Colorectal eligibility wording from the registry: "Histologically and/or cytologically confirmed unresectable metastatic colorectal cancer". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07362836
- Phase: 3
- Setting: Fruquintinib Versus Bevacizumab Plus Chemotherapy as Second-Line Therapy for Patients With RAS-Mutant Metastatic Colorectal Cancer (FRU-RAS): A Multicenter Randomized Controlled Trial
- Sponsor: Fudan University
- Enrolled: 224

## Sources

- ClinicalTrials.gov NCT07362836: https://clinicaltrials.gov/study/NCT07362836

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Fruquintinib](https://onco.cc/drugs/fruquintinib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07362836.json