# Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRC

Source: https://onco.cc/trials/nct07365592/  
OnCo record `nct07365592` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) and capecitabine in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, now recruiting.

## Summary

Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRC is a phase 1/2, randomised interventional study registered as NCT07365592 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 138 participants, started 2026-04-09 and due to reach its primary completion in 2029-12-01. Interventions recorded: Oxaliplatin; Capecitabine; Anti-PD-1 monoclonal antibody; Sitagliptin (DPP4 inhibitor). Conditions listed: Colorectal Cancer. Primary outcome: Adverse events (AEs); Dose limiting toxicities (DLTs); Proportion of patients achieving tumor regression grade 0/1 (TRG 0/1). Colorectal eligibility wording from the registry: "* Pathologically diagnosed colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: Neo-CD
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07365592
- Phase: 1/2
- Setting: A Phase Ib/II Study of Neoadjuvant Chemotherapy Combined With Anti-PD-1 Antibody and DPP4 Inhibitor Sitagliptin for Locally Advanced pMMR Colorectal Cancer
- Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
- Enrolled: 138

## Sources

- ClinicalTrials.gov NCT07365592: https://clinicaltrials.gov/study/NCT07365592

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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