# Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM

Source: https://onco.cc/trials/nct07381309/  
OnCo record `nct07381309` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fOLFIRI (5-FU, leucovorin, irinotecan) in colorectal cancer, run by Jun Huang, not yet recruiting.

## Summary

Oncolytic Virus (H101) + SBRT + Chemotherapy + Targeted Therapy + Immunotherapy for Unresectable CRLM is a phase 2, randomised interventional study registered as NCT07381309 by Jun Huang, with a registry enrolment figure of 114 participants, started 2026-06-01 and due to reach its primary completion in 2028-02-01. Interventions recorded: SBRT; PD-1 Antibody; H101; Target Therapy; FOLFIRI; Chemotherapy. Conditions listed: CRC; Liver Metastasis Colon Cancer. Primary outcome: ORR. Colorectal eligibility wording from the registry: "Patients with pMMR/MSS colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: VVSHIP
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07381309
- Phase: 2
- Setting: Oncolytic Virus (H101) Peritumoral Injection Combined With SBRT, Chemotherapy, Targeted Therapy, and Immunotherapy for Unresectable MSS/pMMR Colorectal Cancer Liver Metastases (CRLM)
- Sponsor: Jun Huang
- Enrolled: 114

## Sources

- ClinicalTrials.gov NCT07381309: https://clinicaltrials.gov/study/NCT07381309

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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