# JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Iri

Source: https://onco.cc/trials/nct07384377/  
OnCo record `nct07384377` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of JSKN003 in colorectal cancer, run by Shanghai JMT-Bio Inc., not yet recruiting.

## Summary

JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Irinotecan is a phase 3, randomised interventional study registered as NCT07384377 by Shanghai JMT-Bio Inc., with a registry enrolment figure of 123 participants, started 2026-02-06 and due to reach its primary completion in 2027-11-30. Interventions recorded: JSKN003; Physician choiced treatment, include: TAS-102, Regorafenib, Fruquintinib.. Conditions listed: HER2-positive Colorectal Cancer. Primary outcome: Progressive Free Survive (PFS) assessed by Independent Review Committee. Colorectal eligibility wording from the registry: "* Unresectable locally advanced or distant metastatic BRAFV600E wild-type colorectal cancer diagnosed histologically or cytologically". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07384377
- Phase: 3
- Setting: A Phase III Trial to Evaluate the Efficacy and Safety of JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Irinotecan
- Sponsor: Shanghai JMT-Bio Inc.
- Enrolled: 123

## Sources

- ClinicalTrials.gov NCT07384377: https://clinicaltrials.gov/study/NCT07384377

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [HER2-amplified colorectal cancer](https://onco.cc/cancers/her2-amplified-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [JSKN003](https://onco.cc/drugs/jskn003/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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