# Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL)

Source: https://onco.cc/trials/nct07387926/  
OnCo record `nct07387926` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Asciminib, Dexamethasone, Vincristine, Blinatumomab, Methotrexate and Cytarabine in acute lymphoblastic leukaemia, run by Novartis Pharmaceuticals, now recruiting.

## Summary

Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL) is a phase 1/2 interventional study registered as NCT07387926 by Novartis Pharmaceuticals, with 50 participants planned, started 2026-07-05 and due to reach its primary completion in 2033-09-19. Interventions recorded: Asciminib Adult formulation, Asciminib Pediatric formulation, Dexamethasone, Vincristine, Blinatumomab and Methotrexate (intrathecal).

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT07387926
- Phase: 1/2
- Setting: Open-label, Phase I/II Study to Evaluate Safety and Efficacy of Asciminib With Chemotherapy Followed by Asciminib Plus Blinatumomab in Pediatric, Adolescent, and Young Adults With Relapsed or Refractory BCR::ABL1-positive (Philadelphia Positive, Ph+) or BCR::ABL1-like (Ph-like) ALL
- Sponsor: Novartis Pharmaceuticals
- Enrolled: 50

## Sources

- ClinicalTrials.gov NCT07387926: https://clinicaltrials.gov/study/NCT07387926

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/)
- drugs: [Asciminib](https://onco.cc/drugs/asciminib/), [Blinatumomab](https://onco.cc/drugs/blinatumomab/), [Cytarabine](https://onco.cc/drugs/cytarabine/), [Dexamethasone](https://onco.cc/drugs/dexamethasone/), [Methotrexate](https://onco.cc/drugs/methotrexate/), [Vincristine](https://onco.cc/drugs/vincristine/)
- companies: [Advanced Accelerator Applications (Novartis)](https://onco.cc/companies/advanced-accelerator-applications/)

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