# Anlotinib Combined With Sintilimab as First-line Treatment for Advanced Non-liver Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct07398326/  
OnCo record `nct07398326` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of anlotinib and sintilimab in colorectal cancer, run by Shanghai Changzheng Hospital, now recruiting.

## Summary

Anlotinib Combined With Sintilimab as First-line Treatment for Advanced Non-liver Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT07398326 by Shanghai Changzheng Hospital, with a registry enrolment figure of 37 participants, started 2026-02-24 and due to reach its primary completion in 2027-12-31. Interventions recorded: anlotinib and sintilimab. Conditions listed: Colorectal Cancer. Primary outcome: Objective response rate. Colorectal eligibility wording from the registry: "* Patients with histologically or cytologically confirmed advanced colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07398326
- Phase: 2
- Setting: Phase II Study of Anlotinib Combined With Sintilimab as First-line Treatment for Advanced Non-liver Metastatic Colorectal Cancer
- Sponsor: Shanghai Changzheng Hospital
- Enrolled: 37

## Sources

- ClinicalTrials.gov NCT07398326: https://clinicaltrials.gov/study/NCT07398326

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Anlotinib](https://onco.cc/drugs/anlotinib/), [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07398326.json