# Neoadjuvant Immunotherapy ± Radiotherapy in MSI-H/dMMR Locally Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct07403877/  
OnCo record `nct07403877` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of nivolumab and ipilimumab in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

Neoadjuvant Immunotherapy ± Radiotherapy in MSI-H/dMMR Locally Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07403877 by Fudan University, with a registry enrolment figure of 114 participants, started 2026-02-01 and due to reach its primary completion in 2031-12-31. Interventions recorded: Nivolumab; Ipilimumab (1mg/kg); PULSAR; Radical surgery; Watch & wait. Conditions listed: Colorectal Cancer (MSI-H). Primary outcome: Complete regression (CR) rate. Colorectal eligibility wording from the registry: "Histopathologically confirmed primary colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TORCH-OPTIMA
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07403877
- Phase: 2
- Setting: A Phase II Randomized Controlled Trial of Neoadjuvant Immunotherapy With or Without Radiotherapy in Locally Advanced Microsatellite Instability-High/Mismatch Repair-Deficient Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 114

## Sources

- ClinicalTrials.gov NCT07403877: https://clinicaltrials.gov/study/NCT07403877

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Ipilimumab](https://onco.cc/drugs/ipilimumab/), [Nivolumab](https://onco.cc/drugs/nivolumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07403877.json