# A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Source: https://onco.cc/trials/nct07428044/  
OnCo record `nct07428044` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of trastuzumab deruxtecan in lung cancer, run by Memorial Sloan Kettering Cancer Center, now recruiting.

## Summary

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer is a phase 2, interventional study registered as NCT07428044 by Memorial Sloan Kettering Cancer Center, with a registry enrolment figure of 14 participants, started 2026-02-13 and due to reach its primary completion in 2027-02-13. Interventions recorded: Trastuzumab Deruxtecan. Conditions listed: Non-Small Cell Lung Cancer; Non-small Cell Lung Cancer Stage II; Non-Small Cell Lung Cancer Stage IIIA; Non-Small Cell Lung Cancer Stage IIIB. Primary outcome: Major Pathologic Response/MPR Rate. Lung eligibility wording from the registry: "* Pathologically documented NSCLC". Sites: Canada, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07428044
- Phase: 2
- Setting: A Phase II Trial of Neoadjuvant Trastuzumab Deruxtecan for Patients With Stage II-III HER2-Amplified or HER2-Mutated Non-Small Cell Lung Cancer (HERCULES)
- Sponsor: Memorial Sloan Kettering Cancer Center
- Enrolled: 14

## Sources

- ClinicalTrials.gov NCT07428044: https://clinicaltrials.gov/study/NCT07428044

## Connected records

- cancers: [HER2-mutant non-small-cell lung cancer](https://onco.cc/cancers/her2-mutant-nsclc/), [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/)
- drugs: [Trastuzumab deruxtecan](https://onco.cc/drugs/trastuzumab-deruxtecan/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07428044.json