# Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)

Source: https://onco.cc/trials/nct07432399/  
OnCo record `nct07432399` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of dexamethasone in colorectal cancer, run by Institute of Oncology Ljubljana, now recruiting.

## Summary

Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study) is a phase 2, randomised interventional study registered as NCT07432399 by Institute of Oncology Ljubljana, with a registry enrolment figure of 100 participants, started 2025-09-01 and due to reach its primary completion in 2027-05-01. Interventions recorded: Lidocaine; Dexamethasone; Placebo. Conditions listed: Colon Cancer; Colorectal Cancer; Perioperative Immune Response. Primary outcome: Change in Serum Cytokine Concentrations (IL-6, IL-8, IL-10, TNF-alpha). Colorectal eligibility wording from the registry: "* Histologically confirmed colon cancer". Sites: Slovenia. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PILDI
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07432399
- Phase: 2
- Setting: Effect of Perioperative Intravenous Infusion of Lidocaine or High Dose Dexamethasone on the Immune Response in Patients Undergoing Surgery for Colon Cancer - The PILDI Study
- Sponsor: Institute of Oncology Ljubljana
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT07432399: https://clinicaltrials.gov/study/NCT07432399

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- drugs: [Dexamethasone](https://onco.cc/drugs/dexamethasone/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07432399.json