# Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE)

Source: https://onco.cc/trials/nct07435584/  
OnCo record `nct07435584` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, not yet recruiting.

## Summary

Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE) is a phase 1/2, interventional study registered as NCT07435584 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 38 participants, started 2026-03-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: Everolimus (Afinitor) tablets. Conditions listed: Colorectal Cancer. Primary outcome: Incidence of Dose-Limiting Toxicities (DLTs); Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "Histologically confirmed metastatic colorectal cancer with documented disease progression after prior standard systemic antitumor therapies, including but not limited to oxaliplatin, fluoropyrimidine, and irinotecan". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: EVER-RECODE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07435584
- Phase: 1/2
- Setting: Everolimus in Refractory Metastatic Colorectal Cancer With CDK12 Deficiency: A Prospective Multicenter Phase Ib/II Study (EVER-RECODE)
- Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
- Enrolled: 38

## Sources

- ClinicalTrials.gov NCT07435584: https://clinicaltrials.gov/study/NCT07435584

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07435584.json