# Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant Advanced Biliary Tract Cancers

Source: https://onco.cc/trials/nct07437287/  
OnCo record `nct07437287` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of FOLFOX in gallbladder cancer and other biliary tract cancers, run by UNICANCER, not yet recruiting.

## Summary

Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant Advanced Biliary Tract Cancers is a phase 2/3, randomised interventional study registered as NCT07437287 by UNICANCER, with a registry enrolment figure of 160 participants, started 2026-07 and due to reach its primary completion in 2030-04. Interventions recorded: mFOLFOX regimen, Mitazalimab. Conditions listed: Biliary Tract Cancer (BTC). Gallbladder cancer is named in the registry entry: "2. Histologically-proven intrahepatic cholangiocarcinoma, extrahepatic (perihilar/distal) cholangiocarcinoma, or gallbladder carcinoma (ampullary carcinoma excluded)". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: CROCOBIL
- Tags: ctgov-ingest; gallbladder-deep-dive
- Registry id: NCT07437287
- Phase: 2/3
- Setting: Countering Immunotherapy Resistance With Novel Combinations in Advanced Biliary Tract Cancers
- Sponsor: UNICANCER
- Enrolled: 160

## Sources

- ClinicalTrials.gov NCT07437287: https://clinicaltrials.gov/study/NCT07437287

## Connected records

- cancers: [Ampullary cancer (ampulla of Vater)](https://onco.cc/cancers/ampullary/), [Biliary tract cancer (all types)](https://onco.cc/cancers/biliary-tract-cancer/), [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Extrahepatic cholangiocarcinoma (perihilar and distal)](https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/), [Gallbladder cancer](https://onco.cc/cancers/gallbladder/), [Intrahepatic cholangiocarcinoma](https://onco.cc/cancers/intrahepatic-cholangiocarcinoma/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups)](https://onco.cc/terms/gallbladder-cancer-in-biliary-trials/)

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