# A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct07438106/  
OnCo record `nct07438106` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by The First Affiliated Hospital with Nanjing Medical University, now recruiting.

## Summary

A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer is a phase 2, interventional study registered as NCT07438106 by The First Affiliated Hospital with Nanjing Medical University, with a registry enrolment figure of 30 participants, started 2026-01-28 and due to reach its primary completion in 2027-10. Interventions recorded: HRS-4642 Injection. Conditions listed: Locally Advanced Pancreatic Cancer With KRAS G12D Mutation. Primary outcome: To evaluate the efficacy of HRS-4642 combined with AG (nab-paclitaxel and gemcitabine) as conversion therapy in patients with locally advanced pancreatic cancer, as measured by the Objective Response Rate (ORR).. Pancreatic eligibility wording from the registry: "Histologically or cytologically confirmed pancreatic ductal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07438106
- Phase: 2
- Setting: A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer
- Sponsor: The First Affiliated Hospital with Nanjing Medical University
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT07438106: https://clinicaltrials.gov/study/NCT07438106

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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