# Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

Source: https://onco.cc/trials/nct07447050/  
OnCo record `nct07447050` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by University of California, Irvine, now recruiting.

## Summary

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial is a phase 2, randomised interventional study registered as NCT07447050 by University of California, Irvine, with a registry enrolment figure of 24 participants, started 2025-12-23 and due to reach its primary completion in 2027-12-31. Interventions recorded: Riluzole; Placebo. Conditions listed: Breast Cancer; Sarcoma; Gastric (Stomach) Cancer; Lung Cancer; Head and Neck Cancer; Colorectal Cancer; Ovarian Cancer; Liver Cancer; Genitourinary Cancer; Gynecologic Cancer. Primary outcome: Change in circulating Brain-Derived Neurotrophic Factor (BDNF) levels over time in cancer patients receiving chemotherapy. Colorectal eligibility wording from the registry: "Patients who are considered not to be of childbearing potential must have a history of being postmenopausal (with a minimum of 1 year without menses), tubal ligation, or hysterectomy". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07447050
- Phase: 2
- Setting: RiluzolE FOr Preventing Cognitive DysfUnction in Cancer PatientS Receiving Chemotherapy (REFOCUS)
- Sponsor: University of California, Irvine
- Enrolled: 24

## Sources

- ClinicalTrials.gov NCT07447050: https://clinicaltrials.gov/study/NCT07447050

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07447050.json