# Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC

Source: https://onco.cc/trials/nct07448077/  
OnCo record `nct07448077` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Hebei Medical University Fourth Hospital, now recruiting.

## Summary

Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC is a phase 2, randomised interventional study registered as NCT07448077 by Hebei Medical University Fourth Hospital, with a registry enrolment figure of 128 participants, started 2026-03-01 and due to reach its primary completion in 2026-03-01. Interventions recorded: Experimental: short-course radiotherapy and immunotherapy; Chemoradiotherapy. Conditions listed: Efficacy and Safety of Short-course Radiotherapy in Total Neoadjuvant Therapy Combined With Enlonstobart for pMMR Locally Advanced Rectal Cancer. Primary outcome: complete response Rate (pCR+cCR ). Colorectal eligibility wording from the registry: "Histologically confirmed adenocarcinoma of the colon, and umor biopsy immunohistochemistry (IHC) indicates pMMR". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07448077
- Phase: 2
- Setting: Short-Course Radiotherapy in Total Neoadjuvant Therapy Combined With Enlonstobart for pMMR Locally Advanced Rectal Cancer: A Prospective, Multicenter, Open-Label, Randomized Controlled Trial
- Sponsor: Hebei Medical University Fourth Hospital
- Enrolled: 128

## Sources

- ClinicalTrials.gov NCT07448077: https://clinicaltrials.gov/study/NCT07448077

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07448077.json