# Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07458529/  
OnCo record `nct07458529` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Seventh Medical Center of PLA General Hospital, now recruiting.

## Summary

Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07458529 by Seventh Medical Center of PLA General Hospital, with a registry enrolment figure of 50 participants, started 2026-02-10 and due to reach its primary completion in 2027-05-05. Interventions recorded: CRT+PD-1 inhibitor+Probio-M9; CRT+PD-1 inhibitor+placebo. Conditions listed: Rectal Cancer, Adenocarcinoma; Neoadjuvant Therapy; Immunotherapy; Probio-M9; Tislelizumab; Randomized. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: "* Biopsy-proven rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NCRIT-PM9
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07458529
- Phase: 2
- Setting: Neoadjuvant Chemoradiotherapy Combined With Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Middle and Low Rectal Cancer: A Single-Center, Prospective, Randomized Controlled Trial (NCRIT-PM9 Trial)
- Sponsor: Seventh Medical Center of PLA General Hospital
- Enrolled: 50

## Sources

- ClinicalTrials.gov NCT07458529: https://clinicaltrials.gov/study/NCT07458529

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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