# Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma

Source: https://onco.cc/trials/nct07463599/  
OnCo record `nct07463599` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by HonorHealth Research Institute, now recruiting.

## Summary

Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma is a phase 1/2, interventional study registered as NCT07463599 by HonorHealth Research Institute, with a registry enrolment figure of 126 participants, started 2026-02-17 and due to reach its primary completion in 2029-01. Interventions recorded: Tegavivint. Conditions listed: Metastatic Colorectal Carcinoma (mCRC); Colorectal Cancer (CRC); Adenomatous Polyposis Coli (APC) Gene Mutation; Catenin Beta-1 (CTNNB1) Gene Mutation. Primary outcome: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]; Maximum Tolerated Dose (MTD)/Administered Dose. Colorectal eligibility wording from the registry: "Histologically and/or cytologically documented metastatic colorectal adenocarcinoma (all other histological types are excluded)". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07463599
- Phase: 1/2
- Setting: A Phase 1/2, Dose Escalation and Expansion Trial to Evaluate the Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma
- Sponsor: HonorHealth Research Institute
- Enrolled: 126

## Sources

- ClinicalTrials.gov NCT07463599: https://clinicaltrials.gov/study/NCT07463599

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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