# Combination of High and Low-Dose Radiotherapy With Immune Therapy and TKI in Advanced Colorectal Cancer: A Phase II Study

Source: https://onco.cc/trials/nct07467590/  
OnCo record `nct07467590` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, not yet recruiting.

## Summary

Combination of High and Low-Dose Radiotherapy With Immune Therapy and TKI in Advanced Colorectal Cancer: A Phase II Study is a phase 2, interventional study registered as NCT07467590 by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, with a registry enrolment figure of 33 participants, started 2026-04-01 and due to reach its primary completion in 2028-04-01. Interventions recorded: High- and Low-Dose Radiotherapy; Anti-Angiogenic TKI and Anti-PD-1 Therapy. Conditions listed: Refractory Colorectal Cancer; Radiotherapy-Induced Immune Priming; Immune Response. Primary outcome: Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "Histologically confirmed microsatellite stable (MSS) / proficient mismatch repair (pMMR) colorectal adenocarcinoma". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TRIUNITE-07
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07467590
- Phase: 2
- Setting: Efficacy of Combined High and Low-Dose Radiotherapy With Immune Therapy and Tyrosine Kinase Inhibitors (TKI) as a Second-Line or Later Treatment Strategy for Advanced Colorectal Cancer: A Single-Arm, Open-Label Phase II Study
- Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Enrolled: 33

## Sources

- ClinicalTrials.gov NCT07467590: https://clinicaltrials.gov/study/NCT07467590

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07467590.json