# Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab

Source: https://onco.cc/trials/nct07486817/  
OnCo record `nct07486817` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Zongertinib, Cisplatin, Carboplatin, Pemetrexed and Pembrolizumab in non-small-cell lung cancer, run by Boehringer Ingelheim, now recruiting.

## Summary

Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab is a phase 2 interventional study registered as NCT07486817 by Boehringer Ingelheim, with 60 participants planned, started 2026-06-04 and due to reach its primary completion in 2027-08-12. Interventions recorded: Zongertinib, Cisplatin, Carboplatin, Pemetrexed and Pembrolizumab.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT07486817
- Phase: 2
- Setting: Beamion 44: A Randomized, Open-label, Multi-center Phase IIa Platform Trial to Evaluate the Safety and Tolerability of Zongertinib Plus Platinum-based Doublet Chemotherapy With or Without Pembrolizumab (and Potential Other Combinations) in Treatment-naïve Patients With Locally Advanced/Metastatic Non-squamous NSCLC With Activating HER2 Mutations
- Sponsor: Boehringer Ingelheim
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT07486817: https://clinicaltrials.gov/study/NCT07486817

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/), [Zongertinib](https://onco.cc/drugs/zongertinib/)
- companies: [Boehringer Ingelheim](https://onco.cc/companies/boehringer-ingelheim/)

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