# Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct07503639/  
OnCo record `nct07503639` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of retlirafusp alfa, SHR-8068, cAPOX (capecitabine, oxaliplatin) and cetuximab in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07503639 by Fudan University, with a registry enrolment figure of 134 participants, started 2026-04 and due to reach its primary completion in 2028-04. Interventions recorded: SHR-1701; SHR-8068; Short-course radiotherapy; XELOX (Capecitabine and Oxaliplatin); PD-L1 antibody; cetuximab β; HRS-7058; HRS-4642. Conditions listed: Locally Advanced Colorectal Cancer. Primary outcome: Complete response (CR) rate: rate of complete response (CR), including the rate of pathologic complete response (pCR) after surgery and the rate of cCR with W&W strategy.. Colorectal eligibility wording from the registry: "Stage II/III colon cancer, or stage II/III rectal cancer located less than 10 cm from the anal verge;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07503639
- Phase: 2
- Setting: An Exploratory Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal Cancer Based on Molecular Subtypes
- Sponsor: Fudan University
- Enrolled: 134

## Sources

- ClinicalTrials.gov NCT07503639: https://clinicaltrials.gov/study/NCT07503639

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [Cetuximab](https://onco.cc/drugs/cetuximab/), [Retlirafusp alfa](https://onco.cc/drugs/retlirafusp-alfa/), [SHR-8068](https://onco.cc/drugs/shr-8068/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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