# Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07528209/  
OnCo record `nct07528209` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07528209 by Sun Yat-sen University, with a registry enrolment figure of 556 participants, started 2026-04-20 and due to reach its primary completion in 2032-04-20. Interventions recorded: Pucotenlimab combine with CAPOX; CAPOX. Conditions listed: Rectal Cancer; pMMR (Microsatellite Stable Rectal Cancer). Primary outcome: 3-year disease-free survival (DFS) rate. Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07528209
- Phase: 3
- Setting: Neoadjuvant CAPOX Plus Pucotenlimab Combined With Selective Radiotherapy Versus CAPOX Combined With Selective Radiotherapy in Patients With Locally Advanced Rectal Cancer：A Multicenter, Phase III, Randomized Clinical Trial
- Sponsor: Sun Yat-sen University
- Enrolled: 556

## Sources

- ClinicalTrials.gov NCT07528209: https://clinicaltrials.gov/study/NCT07528209

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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