# HEADWATERS: Gemcitabine vs Paclitaxel in Metastatic Triple-Negative Breast Cancer in Women of African Ancestry.

Source: https://onco.cc/trials/nct07528768/  
OnCo record `nct07528768` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of gemcitabine in triple-negative breast cancer, run by The University of The West Indies, not yet recruiting.

## Summary

HEADWATERS: Gemcitabine vs Paclitaxel in Metastatic Triple-Negative Breast Cancer in Women of African Ancestry. is a phase 2, randomised interventional study registered as NCT07528768 by The University of The West Indies, with a registry enrolment figure of 750 participants, started 2027-06-01 and due to reach its primary completion in 2034-06-01. Interventions recorded: Gemcitabine (1000 mg/m^2); Paclitaxel 80 mg/m2 weekly. Conditions listed: Triple Negative Breast Cancer; Metastatic Triple-negative Breast Cancer. Triple-negative eligibility wording from the registry: "Histologically confirmed metastatic triple-negative breast cancer (recent biopsy required)". Sites: Barbados, Ghana, Jamaica. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07528768
- Phase: 2
- Setting: Triple-Negative Breast Cancer From the West African Source to the Caribbean Diaspora: A Phase II Randomized Clinical Trial With Correlative Molecular and Population-Stratified Analysis in Women of African Ancestry With Metastatic Triple-Negative Breast Cancer.
- Sponsor: The University of The West Indies
- Enrolled: 750

## Sources

- ClinicalTrials.gov NCT07528768: https://clinicaltrials.gov/study/NCT07528768

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Gemcitabine](https://onco.cc/drugs/gemcitabine/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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