# Low-dose Immunotherapy in Metastatic and Locally Advanced Colorectal and Gastric MSI/dMMR Cancers

Source: https://onco.cc/trials/nct07542262/  
OnCo record `nct07542262` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Blokhin's Russian Cancer Research Center, now recruiting.

## Summary

Low-dose Immunotherapy in Metastatic and Locally Advanced Colorectal and Gastric MSI/dMMR Cancers is a phase 2, randomised interventional study registered as NCT07542262 by Blokhin's Russian Cancer Research Center, with a registry enrolment figure of 128 participants, started 2025-06-03 and due to reach its primary completion in 2028-03-30. Interventions recorded: Low-dose nivolumab; Low-dose nivolumab with/without chemotherapy; Low-dose nivolumab combined with chemotherapy. Conditions listed: Colorectal Cancer; Gastric Cancer. Primary outcome: Pathological complete response (pCR) - for M0; One-year progression-free survival (PFS) - for M1. Colorectal eligibility wording from the registry: "* Histologically confirmed adenocarcinoma of the colon/rectum/stomach;". Sites: Russia. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NIVO402025
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07542262
- Phase: 2
- Setting: Phase II Open-lable Single-center Clinical Study of the Efficacy and Safety of Low-dose Immunotherapy in the Treatment of Patients With Metastatic and Locally Advanced Colorectal and Gastric Cancers With Microsatellite Unstable Phenotype (MSI)/Deficiency of Mismatch Repair System (dMMR)
- Sponsor: Blokhin's Russian Cancer Research Center
- Enrolled: 128

## Sources

- ClinicalTrials.gov NCT07542262: https://clinicaltrials.gov/study/NCT07542262

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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