# A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression

Source: https://onco.cc/trials/nct07546500/  
OnCo record `nct07546500` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Azenosertib in ovarian cancer, now recruiting.

## Summary

A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression is a phase 3 interventional study registered as NCT07546500, led by K-, Beta with European Network of Gynaecological Oncological Trial Groups (ENGOT) and GOG Foundation, and recruiting on the registry. Official title: A Randomised, Open-Label Phase 3 Study of Azenosertib Versus Investigator's Choice of Chemotherapy in Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression. Planned enrolment is 420 participants (estimated). The study started in 2026-04-17 and primary completion is expected in 2028-05-31. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: ASPENOVA
- Tags: ctgov-ingest
- Registry id: NCT07546500
- Phase: 3
- Setting: A Randomized, Open-Label Phase 3 Study of Azenosertib Versus Investigator's Choice of Chemotherapy in Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression
- Sponsor: K-, Beta
- Enrolled: 420

## Sources

- ClinicalTrials.gov NCT07546500: https://clinicaltrials.gov/study/NCT07546500

## Connected records

- cancers: [High-grade serous ovarian cancer](https://onco.cc/cancers/high-grade-serous-ovarian-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Platinum-resistant ovarian cancer](https://onco.cc/cancers/platinum-resistant-ovarian-cancer/)
- drugs: [Azenosertib](https://onco.cc/drugs/azenosertib/)
- companies: [Zentalis Pharmaceuticals](https://onco.cc/companies/zentalis-pharmaceuticals/)

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