# BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases

Source: https://onco.cc/trials/nct07550088/  
OnCo record `nct07550088` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by Darren Sigal, MD, now recruiting.

## Summary

BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases is a phase 2, interventional study registered as NCT07550088 by Darren Sigal, MD, with a registry enrolment figure of 17 participants, started 2026-06-10 and due to reach its primary completion in 2028-09. Interventions recorded: Balstilimab (BAL); Botensilimab (BOT); agenT-797. Conditions listed: Colorectal Cancer Metastatic. Primary outcome: Overall Response Rate (ORR). Colorectal eligibility wording from the registry: "* Adults ≥18 years of age with histologically confirmed metastatic colorectal cancer with liver metastases, including evidence of active liver disease if previously treated locally". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07550088
- Phase: 2
- Setting: A Single-Arm, Phase II Study Evaluating Combination Balstilimab Plus Botensilimab With AgenT-797 in Previously Treated Patients With pMMR Metastatic CRC With Liver Metastases
- Sponsor: Darren Sigal, MD
- Enrolled: 17

## Sources

- ClinicalTrials.gov NCT07550088: https://clinicaltrials.gov/study/NCT07550088

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07550088.json