# Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI

Source: https://onco.cc/trials/nct07551414/  
OnCo record `nct07551414` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in lung cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, not yet recruiting.

## Summary

Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI is a phase 2, interventional study registered as NCT07551414 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 38 participants, started 2026-05-30 and due to reach its primary completion in 2027-05-30. Interventions recorded: Zorifertinib Plus Intra-Ommaya CSF Chemotherapy. Conditions listed: NSCLC (Non-small Cell Lung Carcinoma); Leptomeningeal Metastasis; EGFR-TKI Sensitizing Mutation; Zorifertinib. Primary outcome: Response Assessment in Neuro - Oncology Leptomeningeal Metastases (RANO - LM) criteria. Lung eligibility wording from the registry: "During the screening phase, subjects must be diagnosed with non-small cell lung cancer (NSCLC) and test positive for EGFR-sensitive mutations (L858R and/or Exon 19Del)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07551414
- Phase: 2
- Setting: A Prospective Study of Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI Therapy
- Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Enrolled: 38

## Sources

- ClinicalTrials.gov NCT07551414: https://clinicaltrials.gov/study/NCT07551414

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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