# A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

Source: https://onco.cc/trials/nct07554339/  
OnCo record `nct07554339` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Calderasib in non-small-cell lung cancer, now recruiting.

## Summary

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015) is a phase 3 interventional study registered as NCT07554339, led by Merck Sharp & Dohme, and recruiting on the registry. Official title: A Phase 3, Randomised, Double-blind, Placebo- and Active-Comparator-Controlled Study of MK-1084 Plus Durvalumab Versus Placebo Plus Durvalumab in Participants With Locally Advanced, Unresected KRAS G12C-Mutant Non-Small Cell Lung Cancer Without Disease Progression Following Definitive Platinum-Based Chemoradiotherapy (KANDLELIT-015). Planned enrolment is 310 participants (estimated). The study started in 2026-06-18 and primary completion is expected in 2032-12-15. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: KANDLELIT-015
- Tags: ctgov-ingest
- Registry id: NCT07554339
- Phase: 3
- Setting: A Phase 3, Randomized, Double-blind, Placebo- and Active-Comparator-Controlled Study of MK-1084 Plus Durvalumab Versus Placebo Plus Durvalumab in Participants With Locally Advanced, Unresected KRAS G12C-Mutant Non-Small Cell Lung Cancer Without Disease Progression Following Definitive Platinum-Based Chemoradiotherapy (KANDLELIT-015)
- Sponsor: Merck Sharp & Dohme
- Enrolled: 310

## Sources

- ClinicalTrials.gov NCT07554339: https://clinicaltrials.gov/study/NCT07554339

## Connected records

- cancers: [KRAS G12C-mutant non-small-cell lung cancer](https://onco.cc/cancers/kras-g12c-nsclc/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Calderasib](https://onco.cc/drugs/calderasib/)
- companies: [Merck & Co. (MSD)](https://onco.cc/companies/merck/)

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JSON: https://onco.cc/api/v1/entities/nct07554339.json