# Randomized Trial of Plasma ctDNA Methylation-Guided Adjuvant Therapy in T4N0 and Low-Risk Stage III Colorectal Cancer

Source: https://onco.cc/trials/nct07562503/  
OnCo record `nct07562503` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Randomized Trial of Plasma ctDNA Methylation-Guided Adjuvant Therapy in T4N0 and Low-Risk Stage III Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07562503 by Fudan University, with a registry enrolment figure of 340 participants, started 2024-11-01 and due to reach its primary completion in 2027-12-31. Interventions recorded: CAPEOX regimen; CAPEOX regimen. Conditions listed: ctDNA; Colorectal Cancer; Chemotherapy. Primary outcome: Patient's 2-year Progression-Free Survival. Colorectal eligibility wording from the registry: "Histologically confirmed postoperative pTNM stage high-risk stage II colorectal cancer;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CLEAR-03
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07562503
- Phase: 2
- Setting: Randomized Trial of Plasma ctDNA Methylation-Guided Adjuvant Therapy in T4N0 and Low-Risk Stage III Colorectal Cancer
- Sponsor: Fudan University
- Enrolled: 340

## Sources

- ClinicalTrials.gov NCT07562503: https://clinicaltrials.gov/study/NCT07562503

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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