# Randomized Controlled Study of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy in Stage I/Low-Risk Stage II Colorectal Cancer

Source: https://onco.cc/trials/nct07562659/  
OnCo record `nct07562659` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of capecitabine in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Randomized Controlled Study of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy in Stage I/Low-Risk Stage II Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07562659 by Fudan University, with a registry enrolment figure of 80 participants, started 2024-11-01 and due to reach its primary completion in 2027-12-31. Interventions recorded: Capecitabine. Conditions listed: ctDNA; Colorectal Cancer (CRC); Adjuvant Chemotherapy. Primary outcome: Patient's 2-year Progression-Free Survival. Colorectal eligibility wording from the registry: "Histologically confirmed postoperative pTNM stage high-risk stage II colorectal cancer;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CLEAR-01
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07562659
- Phase: 2
- Setting: A Randomized Controlled Trial of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy Decisions in Postoperative Stage I or Low-Risk Stage II Colorectal Cancer Patients
- Sponsor: Fudan University
- Enrolled: 80

## Sources

- ClinicalTrials.gov NCT07562659: https://clinicaltrials.gov/study/NCT07562659

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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