# Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced

Source: https://onco.cc/trials/nct07581626/  
OnCo record `nct07581626` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Chinese PLA General Hospital, not yet recruiting.

## Summary

Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07581626 by Chinese PLA General Hospital, with a registry enrolment figure of 60 participants, started 2026-05-01 and due to reach its primary completion in 2027-04-01. Interventions recorded: SCRT+targeted therapy+immunotherapy+chemotherapy. Conditions listed: Locally Advanced Rectal Cancer (LARC). Primary outcome: Complete Response (CR). Colorectal eligibility wording from the registry: "* Middle or low rectal cancer located ≤10 cm from the anal verge as assessed by MRI". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07581626
- Phase: 2
- Setting: A Single-Arm, Phase 2 Clinical Study on the Efficacy and Safety of Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer
- Sponsor: Chinese PLA General Hospital
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT07581626: https://clinicaltrials.gov/study/NCT07581626

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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