# Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

Source: https://onco.cc/trials/nct07595874/  
OnCo record `nct07595874` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by City of Hope Medical Center, now recruiting.

## Summary

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3 is a phase 2, interventional study registered as NCT07595874 by City of Hope Medical Center, with a registry enrolment figure of 100 participants, started 2026-12-27 and due to reach its primary completion in 2027-05-27. Interventions recorded: Balstilimab; Biospecimen Collection; Botensilimab; Computed Tomography; Magnetic Resonance Imaging. Conditions listed: Advanced Colon Adenocarcinoma; Advanced Colorectal Adenocarcinoma; Advanced Rectal Adenocarcinoma; Stage IIB Colon Cancer AJCC v8; Stage IIB Rectal Cancer AJCC v8; Stage IIC Colon Cancer AJCC v8; Stage IIC Rectal Cancer AJCC v8; Stage IIIA Colon Cancer AJCC v8; Stage IIIA Rectal Cancer AJCC v8; Stage IIIB Colon Cancer AJCC v8; Stage IIIB Rectal Cancer AJCC v8; Stage IIIC Colon Cancer AJCC v8; Stage IIIC Rectal Cancer AJCC v8. Primary outcome: Two-year disease-free survival rate. Colorectal eligibility wording from the registry: "* Histologically confirmed or cytologically confirmed colorectal adenocarcinoma". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NEST3
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07595874
- Phase: 2
- Setting: A Phase II Novel Exploratory Study to Test Neoadjuvant Immunotherapy Combinations in Patients With Resectable Colon Cancer (NEST3)
- Sponsor: City of Hope Medical Center
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT07595874: https://clinicaltrials.gov/study/NCT07595874

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Balstilimab](https://onco.cc/drugs/balstilimab/), [Botensilimab](https://onco.cc/drugs/botensilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07595874.json