# HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization

Source: https://onco.cc/trials/nct07612007/  
OnCo record `nct07612007` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Mayo Clinic, not yet recruiting.

## Summary

HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization is a phase 2, randomised interventional study registered as NCT07612007 by Mayo Clinic, with a registry enrolment figure of 80 participants, started 2026-09-01 and due to reach its primary completion in 2028-08-01. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Computed Tomography; Darizmetinib; Embolization Therapy; Hepatectomy; Magnetic Resonance Imaging; Placebo Administration; Positron Emission Tomography. Conditions listed: Metastatic Colorectal Carcinoma; Metastatic Malignant Neoplasm in the Liver; Resectable Colorectal Carcinoma; Stage IV Colorectal Cancer AJCC v8. Primary outcome: Future liver remnant size (FLR). Colorectal eligibility wording from the registry: "* REGISTRATION: Individuals with metachronous colorectal carcinoma liver metastases (CRCLM) after resection of the primary OR synchronous CRCLM with planned simultaneous resection of primary and metastatic disease". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07612007
- Phase: 2
- Setting: Phase 2B Study to Determine Efficacy of HRX215, a First Generation MKK4 Inhibitor Drug, in Improving Regeneration of the Remnant Liver After Portal Vein Embolization (PVE) of Colorectal Liver Metastasis (CRLM)
- Sponsor: Mayo Clinic
- Enrolled: 80

## Sources

- ClinicalTrials.gov NCT07612007: https://clinicaltrials.gov/study/NCT07612007

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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