# Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cance

Source: https://onco.cc/trials/nct07617389/  
OnCo record `nct07617389` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Wen-zhao ZHONG, not yet recruiting.

## Summary

Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer (SCIENCE Study) is a phase 3, randomised interventional study registered as NCT07617389 by Wen-zhao ZHONG, with a registry enrolment figure of 358 participants, started 2026-05-20 and due to reach its primary completion in 2030-05-15. Interventions recorded: selective mediastinal lymph node sampling; systematic mediastinal lymph node dissection. Conditions listed: Stage IIA-IIIB NSCLC; Selective Mediastinal Lymph Node Sampling; Systematic medIastinal Lymph Node Dissection. Primary outcome: 2-year event-free survival (EFS) rate. Lung eligibility wording from the registry: "Histologically or pathologically confirmed peripheral non-small cell lung cancer (NSCLC), with clinical tumor, node, metastasis(TNM) stage IIA-IIIB, which according to the International Association for the Study of Lung Cancer(IASLC) 9th edition, and no known epidermal growth factor receptor (EGFR) ". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07617389
- Phase: 3
- Setting: Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemotherapy Combined With Immunotherapy for the Treatment of Clinical Stage IIA-IIIB (N2) Non-small Cell Lung Cancer
- Sponsor: Wen-zhao ZHONG
- Enrolled: 358

## Sources

- ClinicalTrials.gov NCT07617389: https://clinicaltrials.gov/study/NCT07617389

## Connected records

- cancers: [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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