# Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial

Source: https://onco.cc/trials/nct07622771/  
OnCo record `nct07622771` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial is a phase 2, randomised interventional study registered as NCT07622771 by Sun Yat-sen University, with a registry enrolment figure of 84 participants, started 2026-05-26 and due to reach its primary completion in 2028-06-30. Interventions recorded: Adalimumab+NALIRIFOX→Short course radiotherapy →Adalimumab+NALIRIFOX; Adalimumab+NALIRIFOX→Long course chemoradiotherapy →Adalimumab+NALIRIFOX. Conditions listed: Rectal Cancers. Primary outcome: CR rate. Colorectal eligibility wording from the registry: "Locally advanced rectal adenocarcinoma confirmed by histopathology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07622771
- Phase: 2
- Setting: Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial
- Sponsor: Sun Yat-sen University
- Enrolled: 84

## Sources

- ClinicalTrials.gov NCT07622771: https://clinicaltrials.gov/study/NCT07622771

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07622771.json