# A Phase II Study of Pirfenidone Plus PD-1 Inhibitor With or Without Hypofractionated Radiotherapy for Refractory pMMR/MSS Colorectal Cancer

Source: https://onco.cc/trials/nct07644286/  
OnCo record `nct07644286` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Tao Zhang, now recruiting.

## Summary

A Phase II Study of Pirfenidone Plus PD-1 Inhibitor With or Without Hypofractionated Radiotherapy for Refractory pMMR/MSS Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07644286 by Tao Zhang, with a registry enrolment figure of 48 participants, started 2025-12-01 and due to reach its primary completion in 2027-01-25. Interventions recorded: Pirfenidone in combination with a PD-1 inhibitor; hypofractionated radiotherapy. Conditions listed: Colorectal Cancer (CRC). Primary outcome: Progression Free Survival（PFS）. Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed, unresectable locally advanced or metastatic pMMR/MSS colorectal cancer". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07644286
- Phase: 2
- Setting: Phase II Study Evaluating the Safety, Tolerability, and Efficacy of Pirfenidone and PD-1 Inhibitor With or Without Hypofractionated Radiotherapy in Patients With Advanced, Refractory pMMR/MSS Colorectal Cancer
- Sponsor: Tao Zhang
- Enrolled: 48

## Sources

- ClinicalTrials.gov NCT07644286: https://clinicaltrials.gov/study/NCT07644286

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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