# Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer

Source: https://onco.cc/trials/nct07645118/  
OnCo record `nct07645118` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of nivolumab in colorectal cancer, run by Dr. Te Vuong, not yet recruiting.

## Summary

Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer is a phase 2, interventional study registered as NCT07645118 by Dr. Te Vuong, with a registry enrolment figure of 10 participants, started 2026-07 and due to reach its primary completion in 2028-12. Interventions recorded: Nivolumab; HDRBET; Total Mesorectal Excision (TME). Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: Pathologic complete response (pCR). Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma arising within 5 to 15 cm of the anal verge as measured by sigmoidoscopy or MRI". Sites: Canada. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: IMPERIA
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07645118
- Phase: 2
- Setting: Pilot Evaluation of the Immunogenic Potentiation of Neo-adjuvant Brachytherapy Followed by Nivolumab Immunotherapy Without Chemotherapy in Stage II/III Locally Advanced Mismatch Repair Proficient Rectal Cancer
- Sponsor: Dr. Te Vuong
- Enrolled: 10

## Sources

- ClinicalTrials.gov NCT07645118: https://clinicaltrials.gov/study/NCT07645118

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Nivolumab](https://onco.cc/drugs/nivolumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07645118.json