# Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation

Source: https://onco.cc/trials/nct07656376/  
OnCo record `nct07656376` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in pancreatic cancer, run by Jiangxi Kvvit Pharmaceutical Co., Ltd., not yet recruiting.

## Summary

Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation is a phase 2/3, randomised interventional study registered as NCT07656376 by Jiangxi Kvvit Pharmaceutical Co., Ltd., with a registry enrolment figure of 465 participants, started 2027-06-06 and due to reach its primary completion in 2029-02-07. Interventions recorded: DN022150+AG( Stage I ）; DN022150+AG（Stage II）; placebo+AG（Stage II）. Conditions listed: Pancreatic Cancer; Pancreatic Carcinoma. Primary outcome: DLT; PFS as assessed by BICR per RECIST 1.1; OS. Pancreatic eligibility wording from the registry: "Subjects with confirmed KRAS G12D who have not received prior systemic antineoplastic therapy for advanced or metastatic pancreatic cancer". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07656376
- Phase: 2/3
- Setting: Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation
- Sponsor: Jiangxi Kvvit Pharmaceutical Co., Ltd.
- Enrolled: 465

## Sources

- ClinicalTrials.gov NCT07656376: https://clinicaltrials.gov/study/NCT07656376

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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