# Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct07662031/  
OnCo record `nct07662031` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of tovecimig, fOLFIRI (5-FU, leucovorin, irinotecan), fOLFOX (5-FU, leucovorin, oxaliplatin) and fluorouracil (5-FU) in colorectal cancer, run by Washington University School of Medicine, not yet recruiting.

## Summary

Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT07662031 by Washington University School of Medicine, with a registry enrolment figure of 25 participants, started 2026-08-31 and due to reach its primary completion in 2030-08-31. Interventions recorded: Tovecimig; Irinotecan; Leucovorin; 5-Fluorouracil (5-FU). Conditions listed: Colorectal Cancer; Metastatic Colorectal Cancer. Primary outcome: Overall Response Rate (ORR). Colorectal eligibility wording from the registry: "Patients with treated brain metastases are allowed if post-treatment brain-imaging after CNS-directed therapy shows no evidence of progression". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07662031
- Phase: 2
- Setting: A Phase 2 Clinical Trial of Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer
- Sponsor: Washington University School of Medicine
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT07662031: https://clinicaltrials.gov/study/NCT07662031

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Tovecimig](https://onco.cc/drugs/tovecimig/)
- companies: [Compass Therapeutics](https://onco.cc/companies/compass-therapeutics/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07662031.json