# A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Cours

Source: https://onco.cc/trials/nct07669220/  
OnCo record `nct07669220` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of toripalimab in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial) is a phase 2, randomised interventional study registered as NCT07669220 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 76 participants, started 2026-01-01 and due to reach its primary completion in 2028-01-01. Interventions recorded: Short-course Radiotherapy, SCRT; Toripalimab. Conditions listed: Rectal Adenocarcinoma; High-risk Locally Advanced; Short-course Radiotherapy (SCRT); Immunotherapy; FOLFOX. Primary outcome: CCR. Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed pMMR/MSS rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: STAR
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07669220
- Phase: 2
- Setting: A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial)
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 76

## Sources

- ClinicalTrials.gov NCT07669220: https://clinicaltrials.gov/study/NCT07669220

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Toripalimab](https://onco.cc/drugs/toripalimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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