# Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07686640/  
OnCo record `nct07686640` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07686640 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 180 participants, started 2026-08-15 and due to reach its primary completion in 2029-07-15. Interventions recorded: Short-Course Radiotherapy; Consolidation treatment (With ICIs); Consolidation treatment (Without ICIs). Conditions listed: Local Advanced Rectal Cancer; Radiotherapy; Immunotherapy. Primary outcome: Complete Response (CR) Rate. Colorectal eligibility wording from the registry: "* Patients aged 18-75 years with histologically confirmed pMMR/MSS rectal adenocarcinoma are eligible if they have MRI-defined clinical stage II or III disease according to AJCC 8th edition, tumor located within 12 cm from the anal verge, and at least one high-risk feature, including cT4b, cN2, EMVI". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: SCRIT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07686640
- Phase: 3
- Setting: Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer (SCRIT): A Multicenter Phase III Randomized Controlled Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 180

## Sources

- ClinicalTrials.gov NCT07686640: https://clinicaltrials.gov/study/NCT07686640

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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