# Serplulimab Plus Decitabine and CAPOX Before Surgery for Locally Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct07691632/  
OnCo record `nct07691632` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Tianjin Medical University Cancer Institute and Hospital, not yet recruiting.

## Summary

Serplulimab Plus Decitabine and CAPOX Before Surgery for Locally Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT07691632 by Tianjin Medical University Cancer Institute and Hospital, with a registry enrolment figure of 35 participants, started 2026-06-30 and due to reach its primary completion in 2027-12-31. Interventions recorded: Serplulimab + Decitabine + CAPOX (Oxaliplatin + Capecitabine). Conditions listed: Locally Advanced Colorectal Cancer; Colorectal Adenocarcinoma. Primary outcome: Pathological Complete Response Rate. Colorectal eligibility wording from the registry: "* Histologically or pathologically confirmed colorectal adenocarcinoma with no prior antitumor treatment, staged as cT3/cT4N+M0 locally advanced colorectal cancer according to the AJCC/UICC 8th edition based on contrast-enhanced CT or MRI, with colonoscopy and/or diagnostic laparoscopy if clinically". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07691632
- Phase: 2
- Setting: A Single-Arm, Single-Center, Phase II Exploratory Clinical Study of Serplulimab Combined With Decitabine Plus CAPOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer
- Sponsor: Tianjin Medical University Cancer Institute and Hospital
- Enrolled: 35

## Sources

- ClinicalTrials.gov NCT07691632: https://clinicaltrials.gov/study/NCT07691632

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07691632.json