# Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)

Source: https://onco.cc/trials/nct07711002/  
OnCo record `nct07711002` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This study tests a PARP inhibitor; the registry reports that it is not yet recruiting.

## Summary

The registry lists NCT07711002 as not yet recruiting, last updated 2026-07-17. Enrolment is 1330 planned participants, an estimate. Interventions: Saruparib, Placebo, Enzalutamide, Darolutamide, Abiraterone. Primary measures include Radiographic progression-free survival (rPFS). No results are posted in the registry; this does not exclude separate publications.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-10-06
- Registry id: NCT07711002
- Phase: 3
- Setting: A Randomized, Double-Blind, Placebo-Controlled, 2-Cohort, Phase III Study of Saruparib Combined With Physician's Choice of Androgen Receptor Pathway Inhibitor in Patients With Metastatic Hormone-Sensitive Prostate Cancer, Previously Treated With Docetaxel or PSMA-directed 177Lutetium-Containing Therapy Without Disease Progression, and With Prostate-Specific Antigen ≥ 0.2 ng/mL: EvoPAR-Prostate05
- Sponsor: AstraZeneca

## Sources

- ClinicalTrials.gov NCT07711002: https://clinicaltrials.gov/study/NCT07711002

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- targets: [PARP](https://onco.cc/targets/parp/)
- drugs: [Saruparib](https://onco.cc/drugs/saruparib/)

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JSON: https://onco.cc/api/v1/entities/nct07711002.json