# Addition of Platinum-based Chemotherapy to Tislelizumab in PD-L1high Metastatic Non-small Cell Lung Cancer With a High Tumor Burden

Source: https://onco.cc/trials/nct07715396/  
OnCo record `nct07715396` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of tislelizumab and pembrolizumab in lung cancer, run by AIO-Studien-gGmbH, not yet recruiting.

## Summary

Addition of Platinum-based Chemotherapy to Tislelizumab in PD-L1high Metastatic Non-small Cell Lung Cancer With a High Tumor Burden is a phase 3, randomised interventional study registered as NCT07715396 by AIO-Studien-gGmbH, with a registry enrolment figure of 230 participants, started 2026-10-30 and due to reach its primary completion in 2031-10-30. Interventions recorded: Tislelizumab; Tislelizumab Combined With Chemotherapy; Pembrolizumab. Conditions listed: Non-small Cell Lung Cancer Metastatic. Primary outcome: Progression-free survival. Lung eligibility wording from the registry: "Histologically confirmed and treatment-naïve non-small cell lung cancer UICC 9th stage IV". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Also known as: High Five
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07715396
- Phase: 3
- Setting: Addition of Platinum-based Chemotherapy to Tislelizumab in PD-L1high Metastatic Non-small Cell Lung Cancer With a High Tumor Burden
- Sponsor: AIO-Studien-gGmbH
- Enrolled: 230

## Sources

- ClinicalTrials.gov NCT07715396: https://clinicaltrials.gov/study/NCT07715396

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Tislelizumab](https://onco.cc/drugs/tislelizumab/)
- companies: [BeOne Medicines (formerly BeiGene)](https://onco.cc/companies/beone/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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