# A Study of MRG007 Combination Therapy for Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct07737600/  
OnCo record `nct07737600` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of fluorouracil (5-FU), leucovorin (folinic acid), bevacizumab (glioblastoma use), fOLFOX (5-FU, leucovorin, oxaliplatin) and other drugs in colorectal cancer, run by Lepu Biopharma Co., Ltd., not yet recruiting.

## Summary

A Study of MRG007 Combination Therapy for Advanced Colorectal Cancer is a phase 1/2, interventional study registered as NCT07737600 by Lepu Biopharma Co., Ltd., with a registry enrolment figure of 316 participants, started 2026-08 and due to reach its primary completion in 2028-12. Interventions recorded: MRG007; 5-Fluorouracil / Leucovorin Calcium; Bevacizumab; Oxaliplatin; PD-1/VEGF antibody; Capecitabine. Conditions listed: Advanced Colorectal Cancer. Primary outcome: Dose Limiting Toxicity (DLT); Serious Adverse Events (SAEs); Adverse Event (AE). Colorectal eligibility wording from the registry: "Pathologically confirmed, unresectable locally advanced or metastatic colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07737600
- Phase: 1/2
- Setting: Phase Ib/II Clinical Study of the Safety, Tolerability, Pharmacokinetics, and Efficacy of MRG007 Combination Therapy in Patients With Advanced Colorectal Cancer
- Sponsor: Lepu Biopharma Co., Ltd.
- Enrolled: 316

## Sources

- ClinicalTrials.gov NCT07737600: https://clinicaltrials.gov/study/NCT07737600

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Capecitabine](https://onco.cc/drugs/capecitabine/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)
- companies: [Lepu Biopharma](https://onco.cc/companies/lepu-biopharma/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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