# Adaptive Chemotherapy for Pd-l1 High REsEctablE NSCLC: A Chemo-PHREE Trial

Source: https://onco.cc/trials/nct07746388/  
OnCo record `nct07746388` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cemiplimab in lung cancer, run by University of Maryland, Baltimore, not yet recruiting.

## Summary

Adaptive Chemotherapy for Pd-l1 High REsEctablE NSCLC: A Chemo-PHREE Trial is a phase 2, interventional study registered as NCT07746388 by University of Maryland, Baltimore, with a registry enrolment figure of 30 participants, started 2026-09-01 and due to reach its primary completion in 2030-09-01. Interventions recorded: Cemiplimab. Conditions listed: Nsclc; NSCLC Stage II; NSCLC, Stage III; NSCLC Stage IIIB; Resectable Lung Non-Small Cell Carcinoma. Primary outcome: Major pathologic response (MPR). Lung eligibility wording from the registry: "Participants with histologically confirmed stage II-IIIB(N2) NSCLC (per the 9th International Association for the Study of Lung Cancer) with disease that is considered resectable prior to initiation of systemic therapy". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07746388
- Phase: 2
- Setting: Adaptive Chemotherapy for Pd-l1 High REsEctablE NSCLC: A Chemo-PHREE Trial
- Sponsor: University of Maryland, Baltimore
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT07746388: https://clinicaltrials.gov/study/NCT07746388

## Connected records

- cancers: [PD-L1-high non-small-cell lung cancer without a driver mutation](https://onco.cc/cancers/pdl1-high-nsclc/), [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Cemiplimab](https://onco.cc/drugs/cemiplimab/)
- companies: [Regeneron](https://onco.cc/companies/regeneron/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07746388.json