# Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally A

Source: https://onco.cc/trials/nct07750951/  
OnCo record `nct07750951` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Xijing Hospital, now recruiting.

## Summary

Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07750951 by Xijing Hospital, with a registry enrolment figure of 34 participants, started 2026-05-29 and due to reach its primary completion in 2026-11. Interventions recorded: Cindilimab、IBI310、Capecitabine、Oxaliplatin. Conditions listed: MSI-H/dMMR Locally Advanced Rectal Adenocarcinoma. Primary outcome: Pathological complete response (PCR) rate. Colorectal eligibility wording from the registry: "* 4\) The primary lesion is a locally advanced rectal adenocarcinoma with histopathologically confirmed MSI-H/dMMR characteristics". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: sintilimab
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07750951
- Phase: 2
- Setting: Single-arm, Phase II Clinical Study Evaluating the Safety and Efficacy of Sintilimab Combined With IBI-310 and Chemotherapy as Neoadjuvant Therapy for Locally Advanced Rectal Cancer
- Sponsor: Xijing Hospital
- Enrolled: 34

## Sources

- ClinicalTrials.gov NCT07750951: https://clinicaltrials.gov/study/NCT07750951

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07750951.json