# A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

Source: https://onco.cc/trials/nct07752875/  
OnCo record `nct07752875` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by LG Chem, not yet recruiting.

## Summary

A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation is a phase 1/2, interventional study registered as NCT07752875 by LG Chem, with a registry enrolment figure of 250 participants, started 2026-12-01 and due to reach its primary completion in 2032-10-31. Interventions recorded: LG00313112. Conditions listed: Ovarian Cancer; Small Cell Lung Cancer; Non Small Cell Lung Cancer; Colorectal Cancer; Esophageal Cancer; Breast Cancer; Endometrial Cancer; Head and Neck Cancer; Pancreatic Cancer; Locally Advanced Unresectable or Metastatic Solid Tumor. Primary outcome: Phase 1: Number of participants with dose-limiting toxicities (DLTs); Phase 1: Frequency of treatment-emergent adverse events (TEAEs); Phase 1: Frequency of serious adverse events (SAEs). Pancreatic eligibility wording from the registry: "Acute or chronic uncontrolled renal disease, pancreatitis, or liver disease". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07752875
- Phase: 1/2
- Setting: A Phase 1/2, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation
- Sponsor: LG Chem
- Enrolled: 250

## Sources

- ClinicalTrials.gov NCT07752875: https://clinicaltrials.gov/study/NCT07752875

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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