# Phase III Study of HS-10504 Versus Platinum-Based Doublet Chemotherapy in Patients With C797S+ NSCLC

Source: https://onco.cc/trials/nct07754123/  
OnCo record `nct07754123` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of cisplatin and carboplatin in lung cancer, run by Jiangsu Hansoh Pharmaceutical Co., Ltd., not yet recruiting.

## Summary

Phase III Study of HS-10504 Versus Platinum-Based Doublet Chemotherapy in Patients With C797S+ NSCLC is a phase 3, randomised interventional study registered as NCT07754123 by Jiangsu Hansoh Pharmaceutical Co., Ltd., with a registry enrolment figure of 206 participants, started 2026-09-17 and due to reach its primary completion in 2028-08-31. Interventions recorded: HS-10504; platinum-based doublet chemotherapy (Pemetrexed and Cisplatin/Carboplatin). Conditions listed: Advanced or Metastatic NSCLC. Primary outcome: Progression Free Survival (PFS). Lung eligibility wording from the registry: "Histologically or cytologically confirmed locally advanced or metastatic NSCLC (Stage IIIB, IIIC, or IV)". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07754123
- Phase: 3
- Setting: A Randomized, Controlled, Open-Label, Multicenter Phase III Study to Evaluate the Efficacy and Safety of HS-10504 Versus Platinum-Based Doublet Chemotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Harboring EGFR C797S Mutation After Failure of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) Therapy
- Sponsor: Jiangsu Hansoh Pharmaceutical Co., Ltd.
- Enrolled: 206

## Sources

- ClinicalTrials.gov NCT07754123: https://clinicaltrials.gov/study/NCT07754123

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/)
- companies: [Hansoh Pharmaceutical](https://onco.cc/companies/hansoh-pharma/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07754123.json