# Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Rectal Cancer: A Randomized Controlled Trial

Source: https://onco.cc/trials/nct07755124/  
OnCo record `nct07755124` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by West China Hospital, not yet recruiting.

## Summary

Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Rectal Cancer: A Randomized Controlled Trial is a phase 1/2, randomised interventional study registered as NCT07755124 by West China Hospital, with a registry enrolment figure of 140 participants, started 2026-08-14 and due to reach its primary completion in 2028-08. Interventions recorded: Arginine-Deprived Diet; Short-Course Radiotherapy (SCRT); CAPOX + PD-1 Inhibitor. Conditions listed: Rectal Neoplasms. Primary outcome: Complete Response (CR) Rate (pCR + cCR). Colorectal eligibility wording from the registry: "* Locally advanced mid-low rectal cancer staged as cT3, cT4, or node-positive by rectal MRI". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07755124
- Phase: 1/2
- Setting: A Randomized Controlled Trial of Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer
- Sponsor: West China Hospital
- Enrolled: 140

## Sources

- ClinicalTrials.gov NCT07755124: https://clinicaltrials.gov/study/NCT07755124

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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